Cube with:
Diablo’s Horn & Mephisto’s Brain
In Harrogath (Act 5) on Hell to create a Red Portal to Uber Tristram where you’ll fight the 3 Uber Prime Evils at once.

Cube with:
Baal’s Eye & Mephisto’s Brain:
In Harrogath (Act 5) on Hell to create a Red Portal to Uber Tristram where you’ll fight the 3 Uber Prime Evils at once

Cube with:
Key of Terror & Key of Hate
in Harrogath (Act 5) on Hell to create a Red Portal to where you’ll fight one of three Uber Lesser Evils.

Cube with:
Key of Terror & Key of Destruction
In Harrogath (Act 5) on Hell to create a Red Portal to where you’ll fight one of three Uber Lesser Evils.

Cube with:
Key of Hate & Key of Destruction
In Harrogath (Act 5) on Hell to create a Red Portal to where you’ll fight one of three Uber Lesser Evils.

Cube with:
Diablo’s Horn & Baal’s Eye
In Harrogath (Act 5) on Hell to create a Red Portal to Uber Tristram where you’ll fight the 3 Uber Prime Evils at once